Patients with severe systemic lupus erythematosus have increased risk of pericarditis recurrence: JAMA
A new study published in the Journal of American Medical Association showed that younger patients with severe systemic lupus erythematosus (SLE) were more likely to experience a recurrence of pericarditis within the first year following the original diagnosis.
The most prevalent cardiac symptom of systemic lupus erythematosus (SLE) is pericarditis, which is described as inflammation of the serosal sac surrounding the heart. About 20% of SLE patients have pericarditis. From minor chest discomfort that is made worse by resting flat and relieved by leaning forward to crippling symptoms of severe chest pain and dyspnea, patients may have a wide range of symptoms.
The patients may be at higher risk of recurrence due to potential overlapping immunological-mediated pathways, given the widespread immune dysregulation linked to SLE. Yoo Jin Kim and colleagues therefore carried out this study to look at the risk factors and frequency of pericarditis recurrence in SLE patients.
A well-characterized, single-site prospective cohort of a varied group of SLE patients treated at a tertiary medical facility and enrolled between 1988 and 2023 was retrospectively analyzed in this cohort research. The patients with pericarditis who were included in the Hopkins Lupus Cohort were shortlisted.
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