Phototherapy with topical antioxidants, corticosteroids, or calcineurin inhibitors improve vitiligo symptoms: Study
A new study published in The Journal of Dermatological Treatment showed that for vitiligo patients, phototherapy combined with topical antioxidants, corticosteroids, or calcineurin inhibitors may provide better results.
About 0.5–2% of people worldwide suffer from vitiligo, a common acquired hypopigmentary condition marked by the formation of white macules. Dermatologists still have difficulties in stopping depigmentation, stabilizing depigmented lesions, and encouraging vitiligo repigmentation with current therapies. Common choices are 308-nm excimer laser/light (EL) and narrowband ultraviolet B (NB-UVB).
Antioxidants, calcineurin inhibitors, topical corticosteroids, and vitamin D analogs are frequently used in the treatment of vitiligo. However, prolonged topical use may result in negative side effects, including burning and skin atrophy, which should be carefully considered. The restricted ability of traditional meta-analyses and randomized controlled trials (RCTs) to do head-to-head comparisons makes evaluating the relative effectiveness of variable combinations difficult. Thus, to determine which common topical medication works best when paired with phototherapy, an NMA was used for the first time in this study. The results are intended to give medical professionals evidence-based knowledge to help them create individualized treatment plans for individuals with vitiligo.
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