Polymorphism in Vitamin D receptors linked to development of vitiligo

Medically Reviewed By : Dr. Kamal Kant Kohli

Published On 2022-11-11 14:30 GMT | Update On 2022-11-11 14:30 GMT

In a new study published in Journal of Cosmetic Dermatology, it was shown that ApaI and BsmI polymorphisms in vitamin D receptor (VDR) have been linked to vitiligo susceptibility in the Asian population.

The susceptibility to vitiligo may be significantly influenced by polymorphisms in the vitamin D receptor. Numerous research studies have examined the links between Vitamin D receptor (VDR) polymorphisms and the chance of developing vitiligo, although the results are still controversial. In order to ascertain if polymorphisms in the VDR are related to the susceptibility to vitiligo, Young Ho Lee and colleagues carried out this investigation.

Using the PubMed/Medline and Embase databases, VDR polymorphisms in vitiligo patients and controls were found. Through the use of meta-analyses of all individuals as well as Asian, Arab, European, and Latin American groups, the associations between the VDR ApaI, BsmI, TaqI, and TaqI polymorphisms and vitiligo were examined.

The key findings of this review were:

1. 13 studies totaling 2,034 patients and 2,771 controls were incorporated into this meta-analysis.

2. There was no association between vitiligo and the VDR ApaI A allele in any of the participants.

3. However, there was a connection between the VDR ApaI A allele and vitiligo in Asians but not in Europeans or Arabs.

4. Vitiligo has been linked to the VDR ApaI polymorphism in Asians using recessive, dominant, and homozygote contrast models.

5. In a meta-analysis of the VDR BsmI polymorphism, vitiligo and the B allele were significantly associated.

6. For TaqI and FokI polymorphisms, however, no association between vitiligo and VDR polymorphisms was found.

In conclusion, the findings of this study emphasize the need for additional investigation into the associations between VDR polymorphisms and vitiligo in various ethnic groups based on the underlying ethnic variances. Large-scale research on individuals of different races is necessary in order to completely comprehend the role of VDR gene variations in vitiligo development.

Reference:

Lee, Y. H., & Song, G. G. (2022). Association between vitamin D receptor polymorphisms and vitiligo susceptibility: An updated meta‐analysis. In Journal of Cosmetic Dermatology. Wiley. https://doi.org/10.1111/jocd.15474

Article Source : Journal of Cosmetic Dermatology

Disclaimer: This website is primarily for healthcare professionals. The content here does not replace medical advice and should not be used as medical, diagnostic, endorsement, treatment, or prescription advice. Medical science evolves rapidly, and we strive to keep our information current. If you find any discrepancies, please contact us at corrections@medicaldialogues.in. Read our Correction Policy here. Nothing here should be used as a substitute for medical advice, diagnosis, or treatment. We do not endorse any healthcare advice that contradicts a physician's guidance. Use of this site is subject to our Terms of Use, Privacy Policy, and Advertisement Policy. For more details, read our Full Disclaimer here.

NOTE: Join us in combating medical misinformation. If you encounter a questionable health, medical, or medical education claim, email us at factcheck@medicaldialogues.in for evaluation.

Jacinthlyn Sylvia

Jacinthlyn Sylvia, a Neuroscience Master's graduate from Chennai has worked extensively in deciphering the neurobiology of cognition and motor control in aging. She also has spread-out exposure to Neurosurgery from her Bachelor’s. She is currently involved in active Neuro-Oncology research. She is an upcoming neuroscientist with a fiery passion for writing. Her news cover at Medical Dialogues feature recent discoveries and updates from the healthcare and biomedical research fields. She can be reached at editorial@medicaldialogues.in

Comments Policy

Our comments section is governed by our Comments Policy . By posting comments at Medical Dialogues you automatically agree with our Comments Policy , Terms And Conditions and Privacy Policy .

Polymorphism in Vitamin D receptors linked to development of vitiligo

Similar News

Novel dietary Supplement AGA-P Enhances Effectiveness of Parmacological Treatments for Androgenic Alopecia: Study

Bullous Pemphigoid Patients Face Higher Risk of Osteoporosis and Hip Fractures: Study Suggests

Increased TB Risk in Psoriasis Patients on Etanercept Despite Isoniazid Prophylaxis: Study

Dupilumab Shows High Efficacy and Safety in Treating Moderate to Severe Prurigo Nodularis: Study

Topical Dimethylglycine Sodium Salt and Caffeine Shampoo Promising for Treating Male Pattern Baldness: Study

Vitamin B5 Injections Don't Outperform Topical Therapy for Acne, Clinical Trial Reports

US FDA issued warning against manufacturers of mousse or whipped cream sunscreen products

Scientists Grow World's First Fully Functional Human Skin with Blood Supply