Polymorphism in Vitamin D receptors linked to development of vitiligo
In a new study published in Journal of Cosmetic Dermatology, it was shown that ApaI and BsmI polymorphisms in vitamin D receptor (VDR) have been linked to vitiligo susceptibility in the Asian population.
The susceptibility to vitiligo may be significantly influenced by polymorphisms in the vitamin D receptor. Numerous research studies have examined the links between Vitamin D receptor (VDR) polymorphisms and the chance of developing vitiligo, although the results are still controversial. In order to ascertain if polymorphisms in the VDR are related to the susceptibility to vitiligo, Young Ho Lee and colleagues carried out this investigation.
Using the PubMed/Medline and Embase databases, VDR polymorphisms in vitiligo patients and controls were found. Through the use of meta-analyses of all individuals as well as Asian, Arab, European, and Latin American groups, the associations between the VDR ApaI, BsmI, TaqI, and TaqI polymorphisms and vitiligo were examined.
The key findings of this review were:
1. 13 studies totaling 2,034 patients and 2,771 controls were incorporated into this meta-analysis.
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