Psoriasis Closely Associated to Higher Risk of Kidney Stones Finds Study

In a recent study published in The Journal of Dermatology uncovered a significant association between psoriasis, a chronic skin condition, and an increased risk of urolithiasis (kidney stones). The study involved a prospective analysis of a total of 67 psoriasis patients (PS group) and 65 individuals without psoriasis (NPS group) that aimed to explore potential links between psoriasis and urinary metabolic abnormalities.

The findings revealed that 19.4% of individuals in the PS group experienced stone events, compared to 7.7% in the NPS group which indicated a notable correlation between psoriasis and urolithiasis (P < 0.05).

The analysis of 24-hour urine samples proved crucial in understanding the metabolic nuances. The patients with psoriasis exhibited significantly lower median values of 24-hour citrate (P = 0.029) and higher median values of 24-hour urine uric acid (P = 0.005) when compared to their non-psoriatic counterparts.

Hypernatriuria was found to be significantly higher in the PS group (P = 0.027) by adding another dimension to the metabolic irregularities associated with psoriasis.

Also, the severity of psoriasis appeared to play a role in metabolic abnormalities, with hyperuricosuria detected in 10.4% of patients with severe disease compared to 1.5% in those with mild disease (P = 0.027).

These findings not only underscore a heightened risk of kidney stones in psoriasis patients but also shed light on specific metabolic factors contributing to this increased susceptibility. Hypocitraturia, hyperuricosuria, and hypernatriuria were found as key metabolic abnormalities associated with psoriasis, with hyperuricosuria associated to the severity of the disease.

The findings expand our understanding of the systemic impact of psoriasis and also emphasize the importance of holistic healthcare approaches for individuals suffering with this skin condition. The integration of dermatological considerations along with nephrological issue could prove important in managing and mitigating the risk of urolithiasis in psoriasis patients.

Source:

Oğuz, I. D., Oğuz, U., Usta, M., Kulaklı, S., Tosun, A., Demirelli, E., Akşan, B., Emecen, Ö., & Yüzüak, E. (2023). Relationship between psoriasis and urolithiasis. The Journal of Dermatology. https://doi.org/10.1111/1346-8138.17058