Psoriasis does not increase MI risk among patients with end stage renal disease

A new study published in The American Journal of the Medical Sciences shows that psoriasis was not linked to an elevated risk of myocardial infarction (MI) in the end-stage renal disease (ESRD) population, in contrast to earlier research in the general population.

Psoriasis is an inflammatory skin condition that has been linked to an elevated risk of serious vascular events including myocardial infarction in non-dialysis patients, according to prior study. In order to ascertain whether psoriasis poses a sizable risk factor for MI in patients with end-stage renal illness, Naomi Siddiquee and team and conducted the study.

In order to find ESRD patients who began dialysis between 2004 and 2015, researchers searched the United States Renal Data System. Those with at least two psoriasis diagnoses, a diagnosis of MI, and other clinical risk factors were identified using ICD-9 and ICD-10 codes. To investigate the relationship between psoriasis and other risk factors for MI, logistic regression was performed.

The key findings of the study were:

1. Researchers found 6,823 (0.6%) participants with psoriasis and 181,960 (17.1%) subjects with MI out of a cohort of 1,062,693 people.

2. 1,671 (24%) of the 6,823 psoriasis patients experienced a MI.

3. In an unadjusted model, psoriasis was linked to an elevated risk of MI.

4. Psoriasis, however, was not connected to MI after adjusting for demographics, dialysis modality, access type, and several illnesses connected to the Charlson Comorbidity Index.

5. Psoriasis and MI were associated with confounders such as congestive heart failure, pulmonary disease, and consequences from diabetes.

In conclusion, the findings of this study clearly highlight the imminent value of an integrated strategy because comorbidities may affect the choice of psoriasis therapy and results.

Reference:

Siddiquee, N., Waller, J. L., Baer, S. L., Mohammed, A., Tran, S., Siddiqui, B., Padala, S., Young, L., Kheda, M., & Bollag, W. B. (2022). ASSOCIATION OF PSORIASIS WITH MYOCARDIAL INFARCTION IN END-STAGE RENAL DISEASE PATIENTS. In The American Journal of the Medical Sciences. Elsevier BV. https://doi.org/10.1016/j.amjms.2022.08.003