Ruxolitinib cream highly effective in treatment of cutaneous lichen planus: Study
Arizona: Topical ruxolitinib is highly effective for treating cutaneous lichen planus (LP), according to findings from a small pilot study in the Journal of Investigative Dermatology. The transcriptomic analysis provided confirmation of LP being an interferon-driven disease and the downregulation of interferon-stimulated genes (ISGs) corresponds to disease response.
Lichen planus is an inflammatory skin condition that affects the skin and mucosal surfaces. Cutaneous lichen planus is a clinical type of lichen planus that shares similar features on histopathology. Its symptoms can range from none (uncommon) to intense itch.
Ruxolitinib is an inhibitor of Janus kinase 1/2 that blocks signal transduction of a critical cytokine involved in the pathogenesis of cutaneous LP called interferon-gamma. In the prospective phase II study, Aaron R. Mangold, Department of Dermatology, Mayo Clinic Arizona, and colleagues investigated the efficacy of topical ruxolitinib in cutaneous LP and performed transcriptomic analysis pre-and post-therapy.
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