Skin eosinophil counts correlate worse treatment responses in patients with bullous pemphigoid
Israel: A recent study in Acta Dermato-Venereologica has concluded that skin eosinophil counts in bullous pemphigoid patients are linked with worse treatment responses. However, skin eosinophil counts did not correlate with disease severity at the onset.
This retrospective study comprising 137 patients with bullous pemphigoid reviewed the pathology cases to determine the association of eosinophil counts with neurological comorbidities and treatment responses. It found that a high tissue eosinophil count was not linked with the worse disease at baseline but was associated with lower treatment response rates at the 1-, 3-, and 6-month follow-up. Tissue eosinophil counts were also linked with neurologic comorbidities.
Eosinophilic spongiosis and dermal infiltration of eosinophils are prominent features of bullous pemphigoid lesions. Although several observations have revealed the pathogenic role of eosinophils in bullous pemphigoid, few studies have examined the impact of skin eosinophil counts on treatment response and disease severity.
To fill the knowledge gap, Sharon Baum, Department of Dermatology, Sheba Medical Center, Tel HaShomer, Israel and colleagues examined the association between eosinophil counts in skin biopsy samples of 137 bullous pemphigoid patients and their comorbidities, demographic characteristics, treatment response, and disease severity in a retrospective study.
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