Supramolecular salicylic acid peel effective treatment for acne vulgaris: Study
China: A recent study, based on analyses of the skin barrier and microbiota, has revealed that 30% supramolecular salicylic acid (SSA) peel has therapeutic effects in patients with moderate-to-severe acne vulgaris (AV). It is suggested that SSA exerts its effect by modulating the skin microbiome and improving the microenvironment, thus lessening local inflammation.
The findings published in the journal Dermatology and Therapy showed that 30% of SSA treatment affects species diversity and proportions; there was a significant decrease in Staphylococcus species and a decrease in Propionibacterium species. The researchers observed a substantial increase in Caveolin-1 expression and a reduction in the expression of toll-like receptor 2, transforming growth factor beta, and interleukin (IL)-1a, IL-17, and IL-6 in the skin tissue after treatment.
Thirty-per cent SSA is a modified salicylic acid preparation which is safe and effective for treating moderate-to-severe AV. However, there needs to be more clarity on its mechanism of action. Therefore, Xinyi Shao and colleagues from China aimed to assess the role of 30% SSA peels on skin inflammation and microbiota in patients with moderate-to-severe AV.
For this purpose, the researchers enrolled 28 patients and received biweekly 30% SSA peels for two months. They assessed the Global Acne Grading System (GAGS) score, transepidermal water loss (TEWL), skin water content, sebum levels, and pH. At the onset and two weeks after treatment completion, they obtained perilesional skin biopsies and microbial skin samples. A high-throughput sequencing approach was used to characterize the samples, targeting a portion of the bacterial 16S ribosomal RNA gene.
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