Systemic inflammation may play role in association between skin disease severity and CVD in psoriasis: JAMA
Sweden: A recent study has shed light on the intricate relationship between psoriasis, systemic inflammation, and cardiovascular disease (CVD), highlighting the interconnected nature of these health issues. Psoriasis, a chronic inflammatory skin condition, has long been recognized for its impact on skin health, but this research underscores its broader implications, particularly concerning cardiovascular risks.
The study, published in JAMA Dermatology, revealed that psoriasis severity, measured by the Psoriasis Area and Severity Index (PASI), was linked to systemic inflammation. Additionally, PASI and systemic inflammation, assessed through GlycA levels, were connected to CVD, with systemic inflammation potentially mediating the relationship between PASI and CVD.
Psoriasis is linked to an elevated risk of cardiovascular disease, though the precise mechanisms driving this connection remain uncertain. Understanding these pathways could aid in developing targeted treatments and provide insight into how peripheral inflammation, like psoriatic skin lesions, contributes to CVD. With this in mind, Axel Svedbom, Dermatology and Venereology Clinic, Karolinska University Hospital, Stockholm, Sweden, and colleagues aimed to investigate whether systemic inflammation mediates the relationship between psoriasis severity and CVD.
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