Tacrolimus ointment highly efficacious for treatment of facial vitiligo: Study
France: Twice-daily tacrolimus 0.1% ointment over a 6-month course was found to be highly effective for the treatment of facial vitiligo, according to a recent study in the Journal of Investigative Dermatology.
Relapses occurred in 40% of the included patients highlighting the need for maintenance therapy following treatment success.
Topical calcineurin inhibitors are widely used off label in vitiligo. However, there is a lack of placebo-controlled, blinded studies that support their use. Considering this, Khaled Ezzedine, UPEC-Université Paris-Est Créteil, France, and colleagues aimed to compare the efficacy of tacrolimus 0.1% ointment versus vehicle for repigmentation in adult patients with facial vitiligo.
For the purpose, the researchers performed a 24-week multicenter randomized parallel double-blind study with a 24-week post-treatment follow-up extension. It included 42 adult patients with recent facial vitiligo target lesions (<2years) without changes in pigmentation or size over the prior 3 months.
The patients were randomized to receive either tacrolimus 0.1% ointment or vehicle twice daily.
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