Topical application of flutamide 1% gel safely reduces inflammatory lesions of acne vulgaris
Flutamide 1% gel, when applied topically, improves inflammatory lesions of acne vulgaris and is associated with minimal side effects, says Amany Nassar in a recent study published in the Journal of Cutaneous Medicine and Surgery.
In this randomized controlled study of 54 patients with a history of acne vulgaris, half of the participants were treated with topical flutamide 1% gel and the other half were treated with a vehicle for eight weeks. Papule and pustule count reduced significantly in those treated with Flutamide gel, while there was no significant reduction in comedone count.
Acne vulgaris is a dermatological condition. Androgens play an essential role in the complex pathophysiology of the condition. Flutamide is a first-generation nonsteroidal antiandrogen used for acne treatment. In this study, researchers evaluated topical flutamide's therapeutic efficacy and safety in treating acne vulgaris.
The study had two groups, Groups A and B, each had 27 patients having mild to moderate acne vulgaris having inflammatory (papules and pustules) and non-inflammatory (comedones) lesions. Group A received twice daily application of Flutamide topical gel on the face for eight weeks. Group (B) was the control group.
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