Topical human platelet extract and vitamin C both help rejuvenate skin on the dorsal hands: Study

A new study published in the journal of Plastic and Reconstructive Surgery showed that after using the human platelet extract (HPE) and vitamin C  twice a day for 12 to 26 weeks were able to revitalize the skin on the dorsal hands. Traditionally, the face has been the primary target of topical skin-rejuvenating therapies, while the hands and other visible body parts have received less attention. Skin photoaging can be corrected using a variety of efficient therapies.

Topical human platelet extract (HPE) and topical L-ascorbic acid (vitamin C), a well-known antioxidant, are new off-the-shelf cosmetic ingredients that have demonstrated promising outcomes in recent clinical trials. HPE is a leukocyte-depleted allogeneic product made from pooled, apheresed platelets imported from the United States. In order to determine how topical HPE (plated) intense serum (Rion Aesthetics) and vitamin C (C E Ferulic with 15% L-ascorbic acid) affected the skin renewal of dorsal hands after 12 to 26 weeks of twice-daily use, Saranya Wyles and her team carried out this study.

This prospective, long-term study used photographic documentation was used at baseline, 6, 12, and 26-week evaluations to evaluate typical aging-related skin issues. The primary finding of this study was found that at 12 weeks following twice-daily topical application, topical HPE was not inferior to topical vitamin C for improving the fractional areas of wrinkles, brown spots, and luminosity on the dorsal hands. Despite their different function, vitamin C and HPE were both useful skin-rejuvenation therapies.

While vitamin C serves as an antioxidant and free radical seeker, protecting cells from oxidative stress, HPE offers other benefits for skin rejuvenation, including angiogenesis, collagen formation, and inflammatory management. Both compounds in a topical serum, brighten and level out skin tone while reducing photoaging symptoms including wrinkles, erythema, and brown spots when applied consistently as part of a skin care regimen. Only 50% of the overall sample population completed the research between 12 and 26 weeks, and there were few darker skin types (8% Fitzpatrick IV or V, 0 type VI), as well as a limited number of men. Overall, after 12 to 26 weeks of twice-daily topical use, HPE is equally effective as vitamin C to rejuvenate the skin on the dorsal hands.

Source:

Wyles, S., Jankov, L. E., Copeland, K., Bucky, L. P., Paradise, C., & Behfar, A. (2023). A Comparative Study of Two Topical Treatments for Photoaging of the Hands. In Plastic & Reconstructive Surgery (Vol. 154, Issue 5, pp. 978–984). Ovid Technologies (Wolters Kluwer Health). https://doi.org/10.1097/prs.0000000000011240