Topical tacrolimus as effective as corticosteroids for atopic dermatitis in kids: Study

Finland: A new study conducted by A. Salava and team noted that the application of tacrolimus 0.03% and 0.1% ointments and topical corticosteroids (low and moderate potency) is safe in young children with moderate-to-severe atopic dermatitis. Also, they both have comparable efficacy and safety profiles. However, evidence on children under long-term therapy seemed to be inadequate. 

The findings of this study were published in the journal Clinical and Experimental Dermatology on 19th November 2021.

Topical tacrolimus has been used as off-label medication in young children but data regarding children under 2 years of age and long-term treatment remains limited. To fill this knowledge gap, the researchers aimed to evaluate the safety of tacrolimus 0.03 percent and 0.1 percent ointments compared to corticosteroids in young children with atopic dermatitis.

An elaborate 36-month follow-up study was undertaken with 152 young children aged one to three years old who had moderate-to-severe atopic dermatitis. Children were prospectively monitored, and data on infections, illness severity, growth characteristics, immunization reactions, and other relevant laboratory tests were collected thoroughly.