Topical treatment with steroids and vitamin D analogue foam effective in long-term management of psoriasis
France: In a new study conducted by Marjorie Heim and team it was found that in psoriasis patients combined topical treatment with Calcipotriol/Betamethasone foam is effective in reducing cellular influx into lesional skin. Further, this effect was found to be superior to emollient or betamethasone alone.
The findings of this study were published in Experimental Dermatology.
As a chronic inflammatory condition, psoriasis can be difficult for sufferers to manage over the long term. Recent research indicates that combining topical steroid and vitamin D analog foam (calcipotriol/betamethasone) therapy is effective in long-term illness control and lowering the incidence of relapses. Its effects on cytokine production and cellular inflammation are still unknown. In order to determine how topical treatments affect cellular infiltration and cytokine profile in psoriasis patients' lesional skin, this study was carried out.
A randomized, double-blind, monocentric study including 30 patients was conducted. Patients received either a placebo, a combination of betamethasone and calcitriol, betamethasone foam alone, or clobetasol propionate ointment. Before and four weeks after treatment, 4-mm skin samples were obtained from lesional and nonlesional areas. By using immunofluorescence, the cellular infiltration, IFN, and IL-17 were examined. Each patient was in charge of themselves. The evolution of skin inflammation was investigated concurrently with alterations in the tPASI clinical score and epidermal thickness of the patients.
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