Topical Tretinoin effective in nail psoriasis
Source- Grover C, Daulatabad D. Topical tretinoin in the treatment of nail psoriasis. Indian Dermatol Online J 2022;13:126-7.
Topical Tretinoin effective in nail psoriasis- Nail involvement is a common feature of psoriasis commonly overlooked by physicians. It affects approximately 10-78% of psoriasis patients with 5-10% of patients having isolated nail psoriasis.2 Its significant association with arthritis, its resistance to treatment and psychological stress it causes in patients makes it an important feature of psoriasis which needs attention and treatment. Recently a case of nail psoriasis being successfully treated with topical tretinoin was reported in the Indian Dermatology Online Journal.
A 12‑year‑old girl presented with an asymmetric fingernail involvement with distal nail disease in the form of subungual hyperkeratosis, distal onycholysis with proximal erythema, and shortening of nails. No skin or joint manifestations were present in the patient. With the suspicion of nail psoriasis, nail bed biopsy was done which revealed subungual hyperkeratosis, focal parakeratosis with a neutrophilic infiltrate, and absence of any fungal elements confirming the diagnosis of nail psoriasis. The nail disease severity was evaluated using NAPSI (Nail Psoriasis Severity Index) score, which was found to be 25.
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