Topical Triple-Agent FDC Gel Found Most Effective and Safe for Moderate-to-Severe Acne in New Meta-Analysis
USA: Among nearly 20 different agents and treatment combinations, the topical triple-agent fixed-dose combination (FDC) gel proved to be the most effective for treating moderate-to-severe acne, according to a network meta-analysis (NMA). The findings were published online in the Journal of Drugs in Dermatology.
There are several treatment options available for managing moderate-to-severe acne. Topical treatments, such as the triple-agent FDC gel, are often preferred due to their targeted application and reduced risk of systemic side effects compared to oral medications. This gel combines proven acne-fighting agents that work synergistically to address multiple aspects of acne pathology, including inflammation, bacterial growth, and excess oil production.
Julie C Harper, The Dermatology and Skin Care Center of Birmingham, AL, and colleagues aimed to systematically examine the comparative effectiveness (efficacy/safety) of moderate-to-severe acne treatments.
For this purpose, the researchers conducted a systematic literature review (SLR) to identify randomized controlled trials involving at least four weeks of treatment—whether topical, oral, physical, or a combination—for moderate-to-severe facial acne in patients aged nine years and older. The study aimed to evaluate efficacy outcomes, including the percentage of patients achieving a two-grade reduction from baseline and those classified as “clear” or “almost clear” for global severity score (treatment success), as well as the absolute changes in inflammatory (ILs) and noninflammatory lesion counts (NILs).
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