Tranexamic Acid Mesotherapy Effective for Post-Acne Erythema

This clinical trial study was performed in the dermatology clinic on 17 patients with persistent PAE (3 months after acne recovery). Two sessions of treatment were performed by a physician with 2-week intervals; TA was injected as mesotherapy into the right side of each patient's face as the case group, while the opposite side was used as the control group. A Visioface device was used to compare before and after treatment photographs of each side of the face in color mode with quantitative measures such as lesions count, area, and area percent.

Results:

Finally, 15 patients completed treatment sessions. There were statistically significant differences in right side lesions before and after treatment with p-values of 0.047, 0.002, and 0.035 for count, area, and area percent, respectively. There was no significant difference before and after treatment in terms of count, area. and area-percent on the left side.

According to the results of this study, tranexamic acid (TA) injection as mesotherapy for resolving PAE can be effective. However, due to small sample size, further studies are needed.

Reference:

Bazargan, AS, Ziaeifar, E, Abouie, A, Mirahmadi, S, Taheri, A, Gheisari, M. Evaluating the effect of tranexamic acid as mesotherapy on persistent post-acne erythema: A before and after study. J Cosmet Dermatol. 2023; 00:1- 7. doi:10.1111/jocd.15776