Upadacitinib Outperforms Dupilumab in Treating Atopic Dermatitis: Study

Patients in the trial received either upadacitinib starting at 15 mg daily (escalated to 30 mg based on response) or dupilumab at 600 mg initially, followed by 300 mg every two weeks for subjects weighing ≥60 kg. Those weighing less than 60 kg received an initial dose of 400 mg, followed by 200 mg every two weeks.

The key findings of the study were:

• A significantly higher percentage of upadacitinib-treated patients achieved the primary endpoint compared to those treated with dupilumab (19.9% vs 8.9%, P < .0001).

• Upadacitinib also outperformed dupilumab in terms of EASI 90 (40.8% vs 22.5%, P < .0001) and WP-NRS of 0/1 (30.2% vs 15.5%, P < .0001) at the 16-week mark.

• The safety profile of upadacitinib was consistent with previous AD studies, with no new safety concerns identified.

• Both medications had a similar rate of serious adverse events (0.9%).

The results from the LEVEL UP trial suggest that upadacitinib may be a more effective treatment option than dupilumab for patients with moderate-to-severe AD. This can help guide clinicians in selecting the most effective treatments for their patients.

The LEVEL UP trial provides evidence that upadacitinib outperforms dupilumab in treating moderate-to-severe atopic dermatitis, offering higher rates of symptom relief and skin clearance. The safety profile of upadacitinib remains consistent with previous studies, making it a promising option for AD management.

Reference:

New Data Show RINVOQ® (upadacitinib) Demonstrated Superiority Versus DUPIXENT® (dupilumab) Across Primary and All Secondary Endpoints in an Open-Label Head-to-Head Atopic Dermatitis Study. AbbVie. April 25, 2024. https://news.abbvie.com/2024-04-25-New-Data-Show-RINVOQ-R-upadacitinib-Demonstrated-Superiority-Versus-DUPIXENT-R-dupilumab-Across-Primary-and-All-Secondary-Endpoints-in-an-Open-Label-Head-to-Head-Atopic-Dermatitis-Study. Date accessed: April 25, 2024.