Use of Benzoyl peroxide with microencapsulated tretinoin may improve acne lesions

The key findings of this study were as follows:

1. In both trials' main objectives, researchers found that microencapsulated BPO with tretinoin outperformed vehicle cream.

2. In the first research, over one-fifth (39.9%) of patients treated with the combination medication had IGA success, compared to 14.3% in the vehicle group.

3. In the second study, significantly more treated patients (26.8%) attained this endpoint than the vehicle arm (15.1%).

4. In the first and second studies, patients treated with BPO with tretinoin had 21.6 and 16.2 mean inflammatory lesion reductions from baseline, compared to 14.8 and 14.1 reductions in the vehicle groups, respectively.

5. In both studies, treated patients reported 29.7 and 24.2 mean decreases in non-inflammatory lesions from baseline, compared to 19.8 and 17.4 in the vehicle arms, respectively.

6. In all studies, investigators observed that the combination treatment was well tolerated, with the most often reported adverse effects being application site discomfort (10.6%), dryness (4.9%), and exfoliation (4.1%).

"In individuals with moderate to severe acne, encapsulated benzoyl peroxide with tretinoin was a successful and safe fixed-dose regimen," concluded the PI and team.

Reference:

Del Rosso, J., Sugarman, J., Gold, M., Arekapdui, K., & Green, L. (2022). A New Frontier in Acne Treatment: Encapsulated Benzoyl Peroxide and Tretinoin . In SKIN The Journal of Cutaneous Medicine (Vol. 6, Issue 2, p. s16). National Society for Cutaneous Medicine. https://doi.org/10.25251/skin.6.supp.16