Acute Pancreatitis in Youth Linked to Diabetes Risk: Study Identifies Key Predictors
USA: A study published in Digestive and Liver Disease suggests that youths who experience acute pancreatitis may face an increased risk of developing prediabetes or diabetes. Key factors associated with this risk include the severity of the condition, levels of C-reactive protein and interleukin-6, and subcutaneous fat area.
"Within three months, 15.3% of participants developed prediabetes, and 0.7% developed diabetes. At the one-year mark, these rates were 12.5% and 3.5%, respectively," the researchers reported.
Acute pancreatitis (AP) has been linked to an elevated risk of diabetes mellitus (DM). Maisam Abu-El-Haija, Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH, USA, and colleagues aimed to identify clinical, laboratory, and imaging predictors of prediabetes (preDM) and DM in youth following an initial episode of AP.
For this purpose, the researchers conducted a prospective cohort study involving patients aged ≤21 with an initial admission for acute pancreatitis, followed by evaluations at 3 and/or 12 months. Clinical laboratory values, imaging findings, admission course details, and plasma chemokine and cytokine levels collected during the index admission were analyzed for their association with the development of prediabetes or diabetes mellitus. A multivariable regression model was employed to identify predictors of preDM/DM.
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