Blood glucose variability and sleep quality in T2DM linked to Depression and anxiety

In T2 diabetics, blood glucose fluctuations and sleep quality are linked to an increased prevalence of depression and anxiety disorders. The study was published in the journal BMC Endocrine Disorders.  

Diabetes is a pandemic affecting worldwide, causing increased morbidity and mortality. Literature shows that blood glucose fluctuation can be linked with depression and anxiety. Hence, researchers conducted a study to find the association between blood glucose fluctuation, traditional risk factors, and emotional disorders in T2DM. 

182 diabetic patients were enrolled in this study. They were randomized into two groups of depression or anxiety having 81 patients and 101 patients without the emotional disorder. Data were obtained through medical history and questionnaire survey and were analyzed using appropriate statistical methods. 

Key findings: 

• Differences in the proportion of females were statistically significant in comparison to basic information.
• There was no statistical difference in laboratory examination indexes between the two groups.
• The standard deviation of blood glucose (SDBG) and postprandial glucose excursion (PPGE) of the comorbidity group was significantly higher than that of the control group.
• Statistically significant differences in sleep quality, PSQI, and dietary habit between the two groups was found through the questionnaire survey.
• The percentage of cognitive disorder, anxiety, and depression in the female group was significantly higher than that in the male group as per the gender stratification analysis.
• Mini-mental state examination (MMSE), self-rating anxiety scale (SAS), and patient health questionnaire (PHQ-9) scores in the female group were also higher than in the male group.
• Logistic regression analysis results showed that SDBG and sleep quality were associated with emotional disorders in T2DM, and the OR values of these factors were 7.588 and 4.428. 

Thus, the researchers concluded that the increased prevalence of depression and anxiety disorders in T2DM was mainly due to blood glucose fluctuation and sleep quality.

For further reading, click here: Yang, Wei, et al. "The Increased Prevalence of Depression and Anxiety in T2DM Patients Associated With Blood Glucose Fluctuation and Sleep Quality." BMC Endocrine Disorders, vol. 22, no. 1, 2022, p. 232.