Blood sugar levels indicative of β-cell dysfunction in patients with type 2 diabetes: Study
USA: Blood sugar levels in adults with type 2 diabetes (T2D) treated with metformin alone, is strongly associated β-cell dysfunction, finds a recent study in the Journal of Diabetes and its Complications. This implies that efforts for glycemia improvement should focus on interventions to improve β-cell function.
Kristina M. Utzschneidera, University of Washington, Seattle, WA, USA, and colleagues aimed to evaluate the relationship between measures of glycemia with β-cell function and insulin sensitivity in adults with early type 2 diabetes.
For the purpose, the researchers assessed baseline data from 3108 adults with T2DM <10 years treated with metformin alone enrolled in the Glycemia Reduction Approaches in Diabetes.
A Comparative Effectiveness (GRADE) Study -- Using oral glucose tolerance tests, insulin and C-peptide responses and insulin sensitivity were calculated. Regression models evaluated the relationships between glycemic measures (HbA1c, fasting and 2-h glucose), measures of β-cell function and insulin sensitivity.
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