Breast Cancer Treatments Linked to Increased Risk of Type 2 Diabetes
A new study published in Breast Cancer Research and Treatment raised concerns about the potential link between breast cancer and an increased risk of type 2 diabetes (T2D), with a particular focus on the impact of breast cancer treatments.
The research team conducted an extensive search through PubMed, Embase, and references of relevant papers for studies exploring the interplay between breast cancer, its treatments, and the subsequent risk of T2D. Random-effects models were employed to calculate effect estimates and associated 95% confidence intervals concerning the association between breast cancer, adjuvant breast cancer treatments (including endocrine therapy and chemotherapy), and the risk of developing T2D. Publication bias was assessed through the use of funnel plots.
The comprehensive analysis encompassed 15 eligible studies, with 10 of them focusing on T2D risk following breast cancer diagnosis or various treatments. Notably, five studies delved into more than one association.
The findings revealed that patients with a history of breast cancer faced an elevated risk of developing T2D compared to those without breast cancer (Effect Estimate (EE) = 1.23, 95% Confidence Interval (CI) = 1.13–1.33). Similarly, individuals who underwent any form of endocrine therapy exhibited an increased risk of incident T2D (EE = 1.23, 95% CI = 1.16–1.32).
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