Cardio and cerebrovascular risk in maturity onset diabetes of young comparable to type 1 & 2 diabetes patients

A new study found that maturity-onset diabetes of the young (MODY) that is detected by genetic analysis has a greater prevalence than clinical diagnosis and has a risk of incident cardiovascular and cerebrovascular events comparable to that of type 1 and type 2 diabetes. The study results were published in The Journal of Clinical Endocrinology and Metabolism. 

Maturity-onset diabetes of the young (MODY), a rare cause of diabetes, is a group of monogenic disorders characterized by autosomal dominantly inherited non-insulin dependent forms of diabetes classically presenting in adolescence or young adults before the age of 25 years. Diagnosing MODY or type 1 or 2 diabetes in the early stages is necessary to avoid cardiovascular and cerebrovascular complications. Researchers conducted a study to compare the incident risk of cardio-cerebrovascular events in maturity-onset diabetes of the young (MODY), type 1 diabetes, and type 2 diabetes. 

Using whole exome sequencing (WES) type 1 diabetes, type 2 diabetes, and MODY were diagnosed. The occurrence of the first major adverse cardiovascular events (MACE), including acute myocardial infarction, heart failure, stroke, unstable angina pectoris, and cardio-cerebrovascular-related mortality was the primary endpoint. Cox proportional hazards models were applied and adjusted to calculate hazard ratios (HRs) and 95% confidence intervals (CIs) for the incident risk of MACE in type 1 diabetes, type 2 diabetes, MODY, and MODY subgroups in comparison with people without diabetes (control group).