Circulating Insulin-like peptide 5 levels closely linked to insulin resistance among patients with PCOS

An enzyme-linked immunosorbent test was used to determine the levels of circulating INSL5 in the PCOS group (n = 101) and control group (n = 78) groups. Regression models were used to assess the connection between INSL5 and IR.

The key findings of this study were:

1. In those with PCOS, the levels of circulating INSL5 were higher (P 0.001), and they were also substantially correlated with the homeostasis model evaluation of insulin resistance (HOMA-IR, r = 0.434, P 0.001; HOMA-IS, r = 0.432; QUICKI, r = 0.504, P 0.001) and insulin resistance.

2. After adjusting for relevant confounders, the participants with the highest tertile of INSL5 levels were more likely to develop PCOS (odds ratio: 12.591, 95% confidence range 2.616-60.605) than those with the lowest tertile.

3. After controlling for covariates, multiple linear regression analysis also revealed an independent relationship between INSL5 levels and HOMA-IR ( = 0.024, P 0.001).

The findings of this study demonstrated a favorable correlation between the prevalence of PCOS in the Chinese population and the levels of circulating INSL5. Several metabolic-hormonal markers, such as insulin resistance and lipid metabolism parameters, were correlated with INSL5. Furthermore, these findings suggested that IR is probably a mediator in the link between INSL5 and PCOS. Additional research is required to determine the potential function of INSL5.

Reference:

Chen, Y., Chen, J., Li, Y., Wu, Y., Wu, X., Zhang, H., & Zhang, Z. (2023). Insulin-like peptide 5 is associated with insulin resistance in women with polycystic ovary syndrome. In Journal of Diabetes and its Complications (Vol. 37, Issue 7, p. 108493). Elsevier BV. https://doi.org/10.1016/j.jdiacomp.2023.108493