Coffee drinking reduces risk of death in diabetes patients, finds study

Patients with type 2 diabetes are at a risk for developing complications of micro-and macrovascular diseases, and Coffee is one of the most popular beverages around the world known to have active biocompunds like caffeine, chlorogenic acids, and diterpenes that have antioxidant, anti-inflammatory and anti-mutagenic properties in humans.

A new study by Hossein Shahinfar and their team talks about risks of coffee consumption in type 2 diabetic patients relating to cardio vascular diseases. The study is published in Nutrition, Metabolism & Cardiovascular Diseases.

The objective of the study was evaluate the long-term consequences of coffee drinking in patients with type 2 diabetes. Coffee consumption and the risk of mortality from all cause, CVD and, CHD needed t be evaluated.

The researchers used PubMed, Scopus, and Web of Sciences as a search portal until November 2020 for prospective cohort studies evaluating the association of coffee drinking with risk of cardiovascular disease (CVD) and mortality in patients with type 2 diabetes. Two reviewers extracted data and rated the certainty of evidence using GRADE approach. Random-effects models were used to estimate the hazard ratios (HRs) and 95% CIs. Dose response associations were modeled by a one stage mixed-effects meta-analysis.

The researchers included ten prospective cohort studies with 82,270 cases. They found that compared to those with no coffee consumption, the HRs for consumption of 4 cups/ d were 0.79 (95%CI: 0.72, 0.87; n Z 10 studies) for all-cause mortality, 0.60 (95%CI: 0.46, 0.79; n Z 4) for CVD mortality, 0.68 (95%CI: 0.51, 0.91; n Z 3) for coronary heart disease (CHD) mortality, 0.72 (95%CI: 0.54, 0.98; n Z 2) for CHD, and 0.77 (95%CI: 0.61, 0.98; n Z 2) for total CVD events. There was no significant association for cancer mortality and stroke. There was an inverse monotonic association between coffee drinking and all-cause and CVD mortality, and inverse linear association for CHD and total CVD events. The certainty of evidence was graded moderate for all-cause mortality, and low or very low for other outcomes.

The researchers concluded that "Drinking coffee may be inversely associated with the risk of mortality in patients with type 2 diabetes. However, more research is needed considering type of coffee, sugar and cream added to coffee, and history of CVD to present more confident results." They also stated that, more prospective studies considering diabetes duration, degree of glycemic control and medications used could help present more confident conclusions for the long-term consequences of coffee drinking in patients with type 2 diabetes.

For further information:

Hossein Shahinfar, Ahmad Jayedi, Tauseef A. Khan, Sakineh Shab-Bidar "Coffee consumption and cardiovascular diseases and mortality in patients with type 2 diabetes: A systematic review and dose-response meta-analysis of cohort studies" Nutrition, Metabolism & Cardiovascular Diseases (2021) 31, 2526-2538.