Concomitant use of insulin and metformin in Diabetes Patients may enhance healing of diabetic foot ulcer, discovers new research

People with chronic diabetic foot ulcers could soon have a new way to treat their wounds for faster healing and fewer hospital stays. Researchers from Michigan State University and South Shore Hospital have uncovered that the combination of two common diabetes drugs-injectable insulin and orally-administered metformin-increases the amount of metformin at the wound site. As metformin can accelerate wound healing, this could be welcome news for the 18.6 million people worldwide (1.6 million in the U.S.) who develop a diabetic foot ulcer, or DFU, in their lifetimes.

“We collected human exudates from diabetic foot ulcers and analyzed their composition,” said Morteza Mahmoudi, an associate professor in the Department of Radiology and Precision Health Program in the MSU College of Human Medicine. “One of the things that we noticed in the composition of the exudates-which has not been observed anywhere else-was the presence of metformin.

“Until now, pharmacological studies had not found an interaction between insulin and metformin,” he added. “Our study shows that there could be at least an indirect role of consuming both insulin and metformin in a way that metformin can end up in a wound area where it enhances the body’s capacity to heal.”