Dapagliflozin, metformin, or exercise didn't decrease plasma glucagon in individuals with prediabetes
Researchers have found that in individuals with prediabetes, 13 weeks of treatment with dapagliflozin, metformin, or exercise was not associated with changes in fasting or post-OGTT glucagon concentrations, according to a study published in the Journal of Diabetes, Obesity & Metabolism.
Prediabetes is associated with an increased risk of developing type 2 diabetes and cardiovascular disease. Therefore, preventive initiatives aiming to reduce cardiometabolic risk in individuals with prediabetes are needed. It has been shown that lifestyle modification, weight loss, and metformin can reduce the risk of progression from prediabetes to type 2 diabetes.
Therefore, Kim KB Clemmensen and colleagues from the Steno Diabetes Center Copenhagen, Copenhagen, Denmark conducted the present study to To assess the effects of dapagliflozin, metformin and exercise treatment on changes in plasma glucagon concentrations in individuals with overweight and HbA1c-defined prediabetes.
The authors included a total of one-hundred and twenty individuals with overweight (body mass index ≥ 25 kg/m2 ) and prediabetes (HbA1c of 39-47 mmol/mol), all of whom were randomized to a 13-week intervention with dapagliflozin (10 mg once daily), metformin (850 mg twice daily), exercise (30 minutes of interval training 5 days per week) or control (habitual living).
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