Diabetes increases risk of liver fibrosis in obese NAFLD patients: Study
Diabetes Mellitus (DM) is a significant risk factor of liver fibrosis in obese and overweight patients, according to a study published in the Obesity Journal.
A group of researchers conducted a study to assess the impact of diabetes mellitus (DM) on nonalcoholic fatty liver disease (NAFLD) and nonalcoholic steatohepatitis (NASH) with advanced fibrosis prevalence in adults with overweight or obesity in the United States.
Participants (National Health and Nutrition Examination Survey [NHANES] 2015-2016 database) included 834 middle-aged patients with diabetes mellitus (DM) (21.7%) and 3,007 without DM (78.3%). nonalcoholic fatty liver disease (NAFLD) was defined by Fatty Liver Index (FLI) ≥ 60 or United States FLI (USFLI) ≥ 30. Moderate-to-high and high risk of advanced fibrosis was defined by fibrosis-4 index (FIB-4) ≥ 1.67 and ≥ 2.67, respectively, and nonalcoholic fatty liver disease (NAFLD) fibrosis scores > 0.676 also indicated a high risk.
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