Diabetic Retinopathy associated with Higher Risk of DFU & Amputation in diabetes Patients
France: According to a study published in Diabetes/Metabolism Research and Reviews, in type 2 diabetes patients, diabetic retinopathy independently relates to foot ulcers and amputation incidence in hospitalized patients.
Gauthier Borderie, with colleagues, investigated, Is Diabetic Retinopathy (DR) related to Diabetic Foot Ulcer (DFU) development?
DR and IWGDF stratification were registered in hospitalized patients (2009 -2017). The patients had a history of uncontrolled/complicated type 2 diabetes. Until 2020, new Diabetic Foot Ulcers were registered.
Diabetic Retinopathy subjects were categorized by survival analyses and multivariate Cox regression adjusted for confounders.
The study results are:
· There were 522 patients in the study.
· 57.9% were male aged 62 years.
· The subjects had diabetes of a duration of 14±10 years.
· The HbA1c was 8.7±1.8%.
· There were 33.9% macroangiopathies and 44.8% diabetic kidney diseases.
· DFU risk grades were 0 (43.3%), 1 (23.9%), 2 (7.1%), and 3 (25.6%).
· The follow-up period was 52 months.
· There were 58 new Diabetic Foot Ulcers and 18 lower-limb amputations in Diabetic Retinopathy patients present in 140 patients constituting 26.8%.
· There were Adjustments for age, sex and conventional risk factors and complications. The conventional risk factors were diabetes duration and control, arterial hypertension, and dyslipidemia.
· Diabetic Retinopathy was associated with a greater incidence of Diabetic Foot Ulcers.
· Diabetic Retinopathy was related to new DFUs with an HR of 2.51 (Adjusted for the IWGDF classification)
· The HR for amputations was 3.56.
· The relationship persisted in ascending IWGDF grades, with DFU incidence from 2/1000 to 121/1000 patient-years (from grade 0 to 3 and from no DR to DR) and amputations from 0 to 38/1000 patient-years (from grade 0 to 3 and from no DR to DR).
To conclude, In type 2 diabetes, Diabetic retinopathy is independently related to foot ulcers and amputation incidence in hospitalized patients.
Further reading:
Borderie, Gauthier, et al. “Diabetic Retinopathy Relates to the Incidence of Foot Ulcers and Amputations in Type 2 Diabetes.” Diabetes/Metabolism Research and Reviews, Wiley, Dec. 2022. Crossref, https://doi.org/10.1002/dmrr.3605
Disclaimer: This website is primarily for healthcare professionals. The content here does not replace medical advice and should not be used as medical, diagnostic, endorsement, treatment, or prescription advice. Medical science evolves rapidly, and we strive to keep our information current. If you find any discrepancies, please contact us at corrections@medicaldialogues.in. Read our Correction Policy here. Nothing here should be used as a substitute for medical advice, diagnosis, or treatment. We do not endorse any healthcare advice that contradicts a physician's guidance. Use of this site is subject to our Terms of Use, Privacy Policy, and Advertisement Policy. For more details, read our Full Disclaimer here.
NOTE: Join us in combating medical misinformation. If you encounter a questionable health, medical, or medical education claim, email us at factcheck@medicaldialogues.in for evaluation.