Dysregulation of lipid profile may increase risk of breast cancer in women with T2DM

It is already known that women with T2DM expose women have an increased risk of breast cancer.

In this study, the authors determined the contribution of lipids, glucose and blood pressure to this risk based on the multifactorial nature of T2DM using the Dutch database 2004-2013.

The included women were aged 30-80 years without breast cancer history and were followed up for 1 year. Exposures of interest included total cholesterol, high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), triglycerides, glycated haemoglobin A (HbA1c) and systolic blood pressure (SBP).

The key results of this study are:

In 4.45 years' follow-up, 183/ 10,183 women were diagnosed with breast cancer.

There were U-shaped associations with the incidence of breast cancer for total cholesterol and HDL-C at baseline.

In comparison to moderate elevations, There was a significant association of higher breast cancer risks with high total cholesterol with aHR 1.72 and HDL-C with aHR 1.74 levels.

Researchers found that low total cholesterol and HDL-C levels produced insignificant marginal effects with adjusted hazard ratios of 1.44 and 1.43 respectively.

In comparison to medium levels. Women with high LDL-C levels had more often breast cancer diagnoses.

The study emphasized how important balancing lipid profiles is particularly total cholesterol and HDL-C in real-world data set.

They said, “Dysregulation of the lipid profile, not the glucose or blood pressure profiles increases the breast cancer risk in T2DM women.

Further reading:

https://www.unboundmedicine.com/medline/citation/36718225/full_citation