Elevated liver enzyme levels tied to risk of incident type 2 diabetes in obese patients

A total of 1005 subjects [296 men and 709 women, aged 45.7 ± 13.12 years, body mass index (BMI) 39.5 ± 4.86 kg/m2] were followed for a mean period of 14.3 ± 4.44 years. Subjects were evaluated for several metabolic variables, including the triglyceride-glucose index and the presence of metabolic syndrome (IDF 2005 definition), and were subdivided into ALT quartiles.

Results

T2DM developed in 136 subjects, and the difference was significant between the first and the fourth ALT quartile (p = 0.048). Both at univariate analysis and at stepwise regression, ALT quartiles were associated with incident T2DM. Traditional risk factors for T2DM coexisted, with a somehow greater predictive value, such as triglyceride-glucose index, age, arterial hypertension, LDL-cholesterol, and metabolic syndrome.

These data suggest an association between elevated ALT levels and the risk of incident T2DM in obesity.

Reference:

Folli, F., Pontiroli, A.E., Zakaria, A.S. et al. Alanine transferase levels (ALT) and triglyceride-glucose index are risk factors for type 2 diabetes mellitus in obese patients. Acta Diabetol (2023). https://doi.org/10.1007/s00592-023-02209-6

Keywords:

Among, obese, individuals, elevated, liver, enzyme, levels, tied, risk, for, incident, type 2 diabetes, Acta Diabetologic, Folli, F., Pontiroli, A.E., Zakaria, A.S