Estimated glucose disposal rate novel indicator of new-onset CVD in individuals with CKM syndrome: Study

A new study published in the journal of BMC Diabetology and Metabolic Syndrome showed an increased estimated glucose disposal rate (eGDR) was associated with a lower risk of cardiovascular disease (CVD) in people with Cardiovascular-Kidney-Metabolic (CKM) syndrome stages 0–3.

Although the development of cardiovascular diseases is significantly influenced by insulin resistance, little is known about the relationship between the estimated glucose disposal rate (eGDR), an indicator of insulin resistance, and the risk of developing new-onset CVD in people with cardiovascular-kidney-metabolic syndrome stage 0–3.

Given how important CKM syndrome is to the development and occurrence of CVD, it is important to look at the connection between eGDR and CVD incidence in people with CKM syndrome stages 0–3. This work might contribute to a better understanding of CKM and support early integrative actions to reduce the vulnerability of the population to CVD.

The study divided participants into four groups based on their eGDR levels which reflects insulin resistance. Those with the lowest eGDR levels (<7.37 mg/kg/min) served as the reference group, while individuals with higher eGDR levels (≥11.16 mg/kg/min) showed a significantly lower risk of developing CVD. The odds ratios (ORs) for CVD occurrence across increasing eGDR levels were 1.00 (reference), 0.81, 0.72, and 0.74, indicating that individuals with higher eGDR levels had up to a 28% lower risk of developing CVD compared to the reference group.