Exenatide-Dapagliflozin Combo Enhances Kidney Protection: DECREASE Trial
Sodium-glucose cotransporter-2 (SGLT2) inhibitors and glucagon-like peptide-1 receptor agonists (GLP-1RAs) are common hypoglycemic drugs. Previous studies have shown that both exenatide and dapagliflozin improves kidney function. In a recent study, researchers have reported that combined therapy with exenatide and dapagliflozin may have synergistic effects on markers of kidney function compared to either therapy alone or placebo in obese patients with type 2 diabetes. The study findings were published in the Diabetes, Obesity and Metabolism on April 28, 2021.
Sodium‐glucose cotransporter‐2 inhibitors and GLP‐1RAs reduce glycated haemoglobin (HbA1c) through distinct yet complementary mechanisms of action. Because of these different mechanisms, combination treatment with SGLT2 inhibitors and GLP‐1RAs may have synergistic effects. However, there are still limited data on the effects of the combined use of SGLT2 inhibitors and GLP‐1RAs on markers of kidney function. Therefore, Dr Charlotte C. van Ruiten MD and his team conducted a study to evaluate the effects of separate and combined use of the SGLT2 inhibitor dapagliflozin and the GLP‐1RA exenatide on measures of kidney function.
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