Fasting ketone bodies strongly and independently associated with diabetes in general population: Study
Netherlands: Findings from a longitudinal prospective study have shown a strong positive relation between fasting plasma ketone body levels and incident type 2 diabetes (T2D) in the general population. The findings, published in the journal Diabetes have important implications for diabetes prevention including dietary strategies.
There has been a rising incidence and prevalence of type 2 diabetes. Instead of this, the identification of prospective biomarkers that predict type 2 diabetes is increasingly relevant for personalized medicine strategies. Ketone bodies have recently received a renewed interest as potential biomarkers, but there is a lack of data linking these metabolites to diabetes risk. To address this knowledge gap, Tamas Szili-Torok, University Medical Center Groningen, Groningen, the Netherlands, and colleagues investigated a potential association between fasting ketone bodies and incident type 2 diabetes in the general population.
The study was undertaken from the PREVEND cohort and included 3,307 participants from the general population initially free of impaired fasting glucose or diabetes. Nuclear magnetic resonance spectroscopy was used to measure baseline fasting ketone body concentrations.
Type 2 diabetes was defined as self-report of type 2 diabetes diagnosis, nonfasting glucose of ≥11.1 mmol/L, fasting glucose of ≥7.0 mmol/L, or initiation of glucose-lowering medication. Impaired fasting glucose was defined according to the criteria of the WHO reflecting the standard of care in the Netherlands (6.1–7.0 mmol/L).
Disclaimer: This website is primarily for healthcare professionals. The content here does not replace medical advice and should not be used as medical, diagnostic, endorsement, treatment, or prescription advice. Medical science evolves rapidly, and we strive to keep our information current. If you find any discrepancies, please contact us at corrections@medicaldialogues.in. Read our Correction Policy here. Nothing here should be used as a substitute for medical advice, diagnosis, or treatment. We do not endorse any healthcare advice that contradicts a physician's guidance. Use of this site is subject to our Terms of Use, Privacy Policy, and Advertisement Policy. For more details, read our Full Disclaimer here.
NOTE: Join us in combating medical misinformation. If you encounter a questionable health, medical, or medical education claim, email us at factcheck@medicaldialogues.in for evaluation.