First-degree relatives of diabetes patients at increased risk for NAFLD, study finds

The results of this study stated as follow:

1. Non-FDRs and FDRs had substantially different proportions of individuals without NAFLD, with intermediate FLI, and with NAFLD.

2. FLI was one of the metabolic parameters that were found to be independently related to first-degree FHD.

3. Multivariate variance analysis indicated that first-degree FHD and glucose metabolic status had positive relationships with FLI that were independent of each other.

4. Multiple stepwise linear regression analyses revealed that in males, premenopausal women, and postmenopausal women, first-degree FHD was independently and positively linked with FLI.

In conclusion, regardless of glucose metabolic state, first-degree relatives of diabetic individuals were more prone to NAFLD. As a result, even in the absence of diabetes, it is critical to detect and prevent NAFLD in first-degree relatives of diabetic patients.

Reference:

Xiang Hu, Weihui Yu, Lijuan Yang, Wei Pan, Ke Xu, Xueqin Chen, Qianqian Li, Yaozhang Zhang, Gang Chen, Junping Wen, Xuejiang Gu, Xingxing Zhang. First-degree family history of diabetes is associated with nonalcoholic fatty liver disease independent of glucose metabolic status. https://doi.org/10.1016/j.jdiacomp.2021.108083