Genetic predisposition to diabetes decreases risk of thoracic aortic aneurysm

Results

Genetically predicted T2D was inversely associated with the risk of TAA (OR: 0.931, 95% CI 0.870 to 0.997, p = 0.040, IVW method) and AAoD (Beta: -0.065, 95%CI −0.099 to  − 0.031, p = 1.7e−04, IVW method), but not with DAoD (p > 0.05). Genetically predicted FG level was inversely associated with AAoD (Beta: −0.273, 95% CI −0.396 to –0.150, p = 1.41e−05, IVW method) and DAoD (Beta: −0.166, 95% CI −0.281 to −0.051, p = 0.005, IVW method), but not with TAA (p > 0.05). The effect of genetically predicted HbA1c and FI on TAA, AAoD and DAoD did not reach statistical significance (p > 0.05).

Genetic predisposition to T2D decreases the risk of TAA. Genetically predicted T2D is inversely associated with AAoD, but not with DAoD. Genetically predicted FG level was inversely associated with AAoD and DAoD.

Reference:

Zhang, Y., Li, Y., Dai, X. et al. Type 2 diabetes has a protective causal association with thoracic aortic aneurysm: a Mendelian randomization study. Diabetol Metab Syndr 15, 120 (2023). https://doi.org/10.1186/s13098-023-01101-1

Keywords:

Diabetology & Metabolic Syndrome, Zhang, Y., Li, Y., Dai, X, Type 2, diabetes, protective causal, association, thoracic, aortic aneurysm, Mendelian randomization study, Glycated hemoglobin, Fasting glucose, Fasting insulin, Thoracic aortic aneurysm, Aortic diameter, Mendelian randomization