Gestational Diabetes May Accelerate Child's Biological Age, finds study
Children born to mothers who had diabetes during pregnancy may age faster biologically and be at an increased risk for obesity and high blood pressure, according to Rutgers researchers. The study has been published in the journal Epigenetics.
Previous studies have shown a more adverse metabolic risk profile is associated with more advanced biological aging.
The researchers investigated the association between prenatal gestational diabetes mellitus exposure and offspring DNA methylation (DNAm) age at 3–10 years of age in the Tianjin gestational diabetes mellitus Observational Study.
The study explored how more than 1,000 children born to mothers in China aged on a cellular level. Researchers examined their exposure to gestational diabetes in utero and their DNA methylation, or epigenetic age, which indicates how experiences and exposures reflect true biological age even in early childhood.
Accelerated aging, which can be determined by evaluating if a person's estimated DNA methylation age is greater than their chronological age, has been shown to be associated with cardiovascular risks and poor health outcomes later in life.
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