Gestational glucose intolerance tied to risk of future diabetes, study reveals

From 16,836 individuals, there were 2,943 pregnancies with Gestational glucose intolerance, 20,359 with normal glucose tolerance, and 909 with gestational diabetes.

The study led to the following findings:

• After a median of 8.4 years of follow-up, 428 people developed diabetes.
• People with gestational glucose intolerance had increased diabetes risk compared to those with normal glucose tolerance in pregnancy (adjusted hazard ratio [aHR] 2.01).
• Diabetes risk increased with the number of abnormal OGTT values (zero, aHR 1.54; one, aHR 2.97; GDM, aHR 8.26 for each compared with normal glucose tolerance).
• The fraction of cases of diabetes ten years after delivery attributable to GGI and GDM was 8.5% and 28.1%, respectively.

"Gestational glucose intolerance confers an increased risk of future diabetes," the authors wrote. "Routinely available clinical data identify an unrecognized group in which enhanced diabetes screening and prevention may be beneficial."

Reference:

Daryl J. Selen, Tanayott Thaweethai, Carolin C.M. Schulte, Sarah Hsu, Wei He, Kaitlyn James, Anjali Kaimal, James B. Meigs, Camille E. Powe; Gestational Glucose Intolerance and Risk of Future Diabetes. Diabetes Care 2022; dc221390. https://doi.org/10.2337/dc22-1390