GLP1-RAs use carries No Psychiatric Risk, rather Enhances Emotional Well-Being in Overweight Diabetes Patients: JAMA
A recent clinical trial published in the Journal of American Medical Association revealed that among individuals who are overweight, obese, and/or have diabetes, GLP1 receptor agonist (GLP1-RA) treatment does not increase the risk of psychiatric adverse events or depressive symptoms compared to placebo. Instead, it is linked to improved quality of life and healthier eating behaviors, including restrained and emotional eating. These results support the psychiatric safety of GLP1-RAs and highlight their positive impact on both physical and emotional health.
GLP-1 RAs like semaglutide and liraglutide are known for their benefits in managing diabetes and promoting weight loss. However, their impact on mental health has remained an open question, particularly given growing use in non-diabetic populations for weight management.
This meta-analysis reviewed data from trials sourced from MEDLINE, Embase, PsycINFO, and CENTRAL databases, aimed to clarify this issue. All included studies were double-blind, placebo-controlled trials in adults with overweight, obesity, or diabetes and assessed psychiatric, cognitive, or quality of life (QOL) outcomes.
Disclaimer: This website is primarily for healthcare professionals. The content here does not replace medical advice and should not be used as medical, diagnostic, endorsement, treatment, or prescription advice. Medical science evolves rapidly, and we strive to keep our information current. If you find any discrepancies, please contact us at corrections@medicaldialogues.in. Read our Correction Policy here. Nothing here should be used as a substitute for medical advice, diagnosis, or treatment. We do not endorse any healthcare advice that contradicts a physician's guidance. Use of this site is subject to our Terms of Use, Privacy Policy, and Advertisement Policy. For more details, read our Full Disclaimer here.
NOTE: Join us in combating medical misinformation. If you encounter a questionable health, medical, or medical education claim, email us at factcheck@medicaldialogues.in for evaluation.