HbA1c Variability Predicts Cardiovascular Risk in T2DM, reveals research
Researchers have discovered in a new research that Increased HbA1c variability is linked to higher risk of adverse cardiovascular events in patients with type 2 diabetes. Future key predictors of CVD risk include the coefficient of variation (CV), standard deviation (SD), and hemoglobin glycation index (HGI).However the HbA1c variability score (HVS) was not a significant predictor in this study.
Glycated hemoglobin (HbA1c) variability is a crucial indicator for evaluating the stability of long-term glycemic control in patients with diabetes mellitus. This study aimed to clarify the association between HbA1c variability and the risk of incident cardiovascular disease (CVD) and mortality in patients with type 2 diabetes mellitus (T2DM) through a systematic review, thereby providing evidence-based support for the early prevention of adverse cardiovascular events in T2DM patients.
They systematically searched the PubMed, Web of Science, The Cochrane Library, and Embase databases for studies on the association between HbA1c variability and cardiovascular outcomes in patients with T2DM, published from the establishment of each database up to August 5, 2025. Cardiovascular outcomes included the incidence of CVD and CVD-related mortality. Two researchers independently conducted literature screening, data extraction, and risk of bias assessment. Meta-analysis was performed using Review Manager 5.3 software, with hazard ratio (HR) or odds ratio (OR) as the effect size.
HbA1c variability is positively associated with the risk of adverse cardiovascular events in patients with T2DM. Among the indicators of HbA1c variability, the coefficient of variation (CV), standard deviation (SD), and hemoglobin glycation index (HGI) can serve as significant predictors for the risk of cardiovascular disease (CVD) occurrence and mortality. However, the HbA1c variability score (HVS) did not show significant predictive value in this study.
Reference:
Wu C, Li A, Zhu Q, Guo J, Li Y, Gu X, Sun A, Wei M, Gong Y. Glycemic variability of glycated hemoglobin in patients with type 2 diabetes mellitus and the risk of cardiovascular diseases: a latest systematic review and meta-analysis. Front Endocrinol (Lausanne). 2025 Nov 6;16:1698360. doi: 10.3389/fendo.2025.1698360. PMID: 41282290; PMCID: PMC12629938.
Keywords:
Wu C, Li A, Zhu Q, Guo J, Li Y, Gu X, Sun A, Wei M, Gong Y, Glycemic, variability, glycated, hemoglobin, patients, type 2 diabetes, mellitus, risk, cardiovascular diseases, latest
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