High BMI Before T2D Onset tied with Advanced Diabetic Complications: BMJ

Results:

Univariate analyses suggested that MBBO was associated with advanced retinopathy and nephropathy, while BMI on admission was associated only with advanced nephropathy. In multivariate analyses, MBBO was significantly associated with advanced complications, while BMI on admission was not. For advanced diabetic retinopathy, the AUCs were 0.70–0.72, and for advanced nephropathy, the AUCs were 0.81–0.83. When comparing the AUCs among models, the models with MBBO sustained high predictive performance for diabetic complications.

Thus, MBBO was independently associated with advanced diabetic complications, while BMI on admission was not. Diabetic microvascular complications in patients with high MBBO could progress more rapidly. At the time of the diagnosis of diabetes mellitus, MBBO would enable us to predict the progress of diabetic complications.

Reference:

Ozawa H, Fukui K, Komukai S, et al. Maximum body mass index before the onset of type 2 diabetes is independently associated with advanced diabetic complications. BMJ Open Diabetes Res Care. 2021;9:e002466.

https://drc.bmj.com/content/9/2/e002466