High HDL-C Linked to Increased Risk of Low Muscle Mass in Older Men: Study Reveals
China: A recent study conducted in China has shed light on a surprising link between high levels of high-density lipoprotein cholesterol (HDL-C)—often termed "good cholesterol"—and a greater risk of low muscle mass in older adults, especially men. The research, published in Frontiers in Endocrinology, was led by Dr. Weixiao Zhang from the Department of Nuclear Medicine at Nanjing BenQ Medical Center, affiliated with Nanjing Medical University.
The investigation involved 1,995 adults aged 50 and above, aiming to explore the connection between HDL-C levels and chest CT-defined muscle mass. Researchers measured the muscle area of the erector spinae at the T12 vertebral level and analyzed how HDL-C levels corresponded with low muscle mass, a key indicator of sarcopenia.
The study led to the following findings:
- Higher HDL-C levels were consistently linked to reduced muscle area in older adults.
- The association was stronger in men (β = -3.16) compared to the overall group (β = -1.91).
- There was no statistically significant association between HDL-C levels and muscle area in women.
- Elevated HDL-C levels more than doubled the risk of low muscle mass in the entire cohort (OR = 2.28).
- In older men, the risk of low muscle mass was three times higher with increased HDL-C levels (OR = 3.28).
- The sex-specific differences suggest a stronger adverse effect of high HDL-C on muscle health in men than in women.
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