High Serum DPP4 Level Might Cause Cognitive Decline in Perinatal Pregnant Women With GDM
The global incidence of DM during pregnancy is 15%, of which gestational diabetes mellitus (GDM) comprises 87.5% of cases. In a recent study, researchers have found a significant cognitive dysfunction in perinatal pregnant women with GDM which was linked with elevated DPP4 levels. The study findings were published in the World Journal of Clinical Cases on November 26, 2021.
Recent studies have shown that type 2 diabetes mellitus (T2DM) can lead to cognitive dysfunction, which mostly manifests as impairments in various abilities such as memory and orientation. Zheng et al. demonstrated altered DPP4 activity could be a risk factor for cognitive dysfunction in T2DM. However, only a few studies have examined the presence of altered cognitive function in patients with GDM. Therefore, Dr En-You Li and his team conducted a study to assess a possible relationship between serum DPP4 and cognitive function in perinatal pregnant women with gestational diabetes mellitus (GDM).
In this case-control study, the researchers divided participants into divided into three groups: GDM group (n = 81), healthy pregnant (HP) group (n = 85), and control group (n = 51). They used the Montreal Cognitive Assessment (MoCA) to assess the cognitive status of each group. They collected a 3mL venous blood sample to measure blood lipids, glycated haemoglobin, and glucose levels. They further used ELISA to detect DPP4, interleukin-6 (IL-6), and 8-iso-prostaglandin F2α (8-iso-PGF2α), and brain-derived neurotrophic factor (BDNF) in blood samples.
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