High serum leptin linked to Aortic stiffness in diabetes patients

1. In the group of patients with aortic stiffness, 46 diabetics with cfPWVs greater than 10 m/s were included.

2. Aortic stiffness group (n = 82) was substantially older (p = 0.019) than the control group (n = 82), and it had higher body fat mass (p = 0.002), systolic blood pressure (SBP), serum triglycerides (p = 0.02), and serum leptin (p 0.001).

3. Aortic stiffness was also linked to insulin resistance and worse blood sugar regulation (p = 0.026).

4. Age, SBP ( = 0.176; p = 0.033), the logarithmically transformed urinary albumin-creatinine ratio, and serum leptin levels were all independently associated with cfPWV values in the multivariable linear regression analyses examining the correlations between aortic stiffness and clinical variables.

5. Only leptin, according to the analysis, was linked to a greater likelihood of aortic stiffness.

Reference:

Wu, T.-J., Wu, D.-A., & Hsu, B.-G. (2023). Serum Leptin Level is Positively Correlated with Aortic Stiffness in Patients with Type 2 Diabetes Mellitus. In Frontiers in Bioscience-Landmark (Vol. 28, Issue 6, p. 128). IMR Press. https://doi.org/10.31083/j.fbl2806128