Hypothalamic gliosis tied to impaired glucose homeostasis in obesity and type 2 diabetes: Study
Written By : Medha Baranwal
Medically Reviewed By : Dr. Kamal Kant Kohli
Published On 2022-01-24 04:30 GMT | Update On 2022-01-24 05:33 GMT
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Seattle, WA: A recent study in the journal Diabetes Care has suggested a role of hypothalamic gliosis in insulin resistance progression in obesity and hence in the pathogenesis of type 2 diabetes (T2D) in humans.
Preclinical research had indicated hypothalamic glial cell responses to be involved in the pathogenesis of obesity and type 2 diabetes. In the study, Ellen A. Schur, UW Medicine Diabetes Institute, University of Washington, Seattle, WA, and colleagues aimed to translate such findings to humans by testing of radiologic markers of gliosis in the mediobasal hypothalamus (MBH) were higher in patients with obesity and impaired glucose homeostasis or T2D in a cross-sectional and prospective cohort study.
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