In Type 1 Diabetes, ketoacidosis not tied with poor long-term metabolic control in kids: Study

The Results of the study are as follows:

• 85 children at the median age of 7.93 years had diabetic ketoacidosis (DKA) at diabetes diagnosis.
  
• The median pH was 7.19.
• Continuous subcutaneous insulin infusion (CSII) was used in 87% of participants in each group. No differences in HbA1C level (7,3%vs7,2%;p = .413) were noted after 5 years of disease duration.
• The severity of ketoacidosis exerted no significant effect on HbA1C.
• The method of insulin delivery at baseline was significantly associated with HbA1C levels after 5 years of observation, βCSII = − 1.46,95%CI[− 2.01 to − 0.92],p < .001.

Thus, the researchers concluded that the presence of diabetic ketoacidosis (DKA) at diabetes diagnosis is not associated with deteriorated long-term metabolic control in children using modern technologies. The early implementation of CSII into diabetes treatment may change the effect of diabetic ketoacidosis (DKA) and lead to a long-term HbA1C improvement.

Reference:

Is diabetic ketoacidosis a good predictor of 5-year metabolic control in children with newly diagnosed type 1 diabetes? By Kowalczyk Emilia et al. published in the BMC Endocrine Disorders.

https://doi.org/10.1186/s12902-021-00882-8