Intact Fish Skin Graft Outperforms Standard Care in Healing Deep Diabetic Foot Ulcers: Study Reveals
France: Recent research published in NEJM Evidence has revealed that using intact fish skin grafts is significantly more effective than standard care in treating deep diabetic foot ulcers. This innovative approach enhances the rate of wound healing and accelerates the healing process, offering new hope for patients battling this challenging condition.
Diabetic foot ulcers are a common complication for individuals with diabetes, often leading to serious infections and, in severe cases, amputations. Traditional treatment methods, which typically involve standard dressings and wound care, have shown limited effectiveness, prompting healthcare professionals to explore alternative therapies. The introduction of intact fish skin grafts has emerged as a promising solution. Considering this, Dured Dardari, Diabetology Department, Center Hopitalier Sud Francilien, Corbeil-Essonnes, France, and colleagues aimed to evaluate the effectiveness of intact fish skin grafts compared to standard care in promoting wound healing and reducing healing time in patients with deep diabetic foot ulcers.
For this purpose, the researchers conducted an international, open-label randomized controlled trial, in which patients with diabetic ulcers penetrating to bone, joint, or tendon were randomly assigned in a 1:1 ratio to receive either intact fish skin grafts or standard wound care. The assigned treatment was applied for 14 weeks.
The primary endpoint was the proportion of ulcers healed at 16 weeks, defined as reepithelialization identified by the investigator and confirmed 14 days later. Healing assessments were also conducted at 20 and 24 weeks, with confirmation of healing at both time points carried out by a blinded adjudication committee.
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