Long acting insulin analogue tied to low risk of sudden fall of blood sugar: JAMA
USA: The use of long-acting insulin analogs versus NPH insulin lowers the risk of severe hypoglycemia in older patients with type 2 diabetes (T2D), finds a recent study in the journal JAMA Internal Medicine.
Previous studies found no difference in the risk of severe hypoglycemia or sudden fall of blood sugar between the use of long-acting insulin analogs and neutral protamine Hagedorn (NPH) insulin in T2D patients. However, these studies were not focused on patients 65 years or older who are at increased hypoglycemia risk, or did not included patients with concomitant prandial insulin use.
Marie C. Bradley, S Food and Drug Administration, Silver Spring, Maryland, and colleagues aimed to examine the risk of emergency department (ED) visits or hospitalizations for hypoglycemia among older community-residing patients with type 2 diabetes who initiated long-acting insulin or NPH insulin in real-world settings.
For the purpose, the researchers performed a retrospective, new-user cohort study and assessed Medicare beneficiaries 65 years or older who initiated insulin glargine (n = 407 018), insulin detemir (n = 141 588), or NPH insulin (n = 26 402) from January 1, 2007, to July 31, 2019.
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