Long-term systolic BP variability tied to type 2 diabetes incidence: Study

For this purpose, the researchers followed a cohort of 3017 Japanese patients (2446 male, 571 female) aged 36–65 years from 2007 through March 31, 2019. The slope of systolic BP change and the root-mean-square error (RMSE) regressed on year were calculated individually using SBP values obtained from 2003 to baseline (2007).

To estimate hazard ratios (HRs), a multivariable Cox proportional hazard model was applied for tertiles of SBP RMSE and continuous SBP slopes after adjusting for age, sex, smoking status, regular exercise, sodium intake, family history of diabetes, sleep disorder, body mass index (BMI), SBP, and fasting blood glucose (FBG) at baseline, and BMI slope from 2003 to 2007. 

Based on the findings the researchers conclude, that "long-term SBP variability was significantly associated with an increased incidence of T2DM independent of baseline age, BMI, sex, FBG, SBP, lifestyle factors and BMI slope from 2003 until baseline.

Reference:

Song, Z., He, Y., Chiang, C. et al. Long-term variability and change trend of systolic blood pressure and risk of type 2 diabetes mellitus in middle-aged Japanese individuals: findings of the Aichi Workers' Cohort Study. Hypertens Res (2022). https://doi.org/10.1038/s41440-022-00993-2